Chapter 78 Metronomic Chemotherapy

  1. Burton JH et al: Low-dose cyclophosphamide selectively decreases regulatory T cells and inhibits angiogenesis in dogs with soft tissue sarcoma, J Vet Intern Med 25:920, 2011. PUBMED Abstract
  2. Elmslie RE, Glawe P, Dow SW: Metronomic therapy with cyclophosphamide and piroxicam effectively delays tumor recurrence in dogs with incompletely resected soft tissue sarcomas, J Vet Intern Med 22:1373, 2008. PUBMED Abstract
  3. Kerbel RS, Kamen BA: The anti-angiogenic basis of metronomic chemotherapy, Nat Rev Cancer 4:423, 2004. PUBMED Abstract
  4. Lana S et al: Continuous low-dose oral chemotherapy for adjuvant therapy of splenic hemangiosarcoma in dogs, J Vet Intern Med 21:764, 2007. PUBMED Abstract
  5. Leach TN et al: Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer, Vet Comp Oncol 10:102, 2012. PUBMED Abstract
  6. Marchetti V et al: First-line metronomic chemotherapy in a metastatic model of spontaneous canine tumours: a pilot study, Invest New Drugs 30(4):1725, 2012. PUBMED Abstract
  7. Mitchell L, Thamm DH, Biller BS: Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer, J Vet Intern Med 26:355, 2012. PUBMED Abstract
  8. Mutsaers AJ: Antiangiogenic and metronomic therapy. In Withrow SJ, Vail DM, Page RL, editors: Withrow and MacEwen's small animal clinical oncology, ed 5, St Louis, 2012, Saunders.
  9. Pasquier E, Kavallaris M, Andre N: Metronomic chemotherapy: new rationale for new directions, Nat Rev Clin Oncol 7:455, 2010. PUBMED Abstract
  10. Selting KA et al: Evaluation of satraplatin in dogs with spontaneously occurring malignant tumors, J Vet Intern Med 25:909, 2011. PUBMED Abstract
  11. Simcock JO et al: Evaluation of a single subcutaneous infusion of carboplatin as adjuvant chemotherapy for dogs with osteosarcoma: 17 cases (2006-2010), J Am Vet Med Assoc 241:608, 2012. PUBMED Abstract
  12. Tripp CD et al: Tolerability of metronomic administration of lomustine in dogs with cancer, J Vet Intern Med 25:278, 2011. PUBMED Abstract